Protein provides clues to foot-and-mouth virus

Wednesday 04 October 2017 2 weeks ago 43   London    Print

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Report  Web Desk : LONDON: Researchers have identified a tiny protein that plays a significant role in the replication of hand-foot-and-mouth disease. Hand-foot-and-mouth disease primarily affects young children and is caused by infection with the coxsackievirus A16 causing fever, sore throat, blisters in the mouth, and a rash on the hands and feet. Hand-foot-and-mouth disease is most common in children in child care settings because of frequent diaper changes and potty training, and because little children often put their hands in their mouths. Researchers have identified a new role for a small viral protein 3B3. The study showed how these viruses can replicate themselves. “By understanding the role of this tiny viral protein in the replication of foot-and-mouth disease virus, we’re hoping to find more effective vaccines that fight the disease,” Nicola said. The study found that positive-strand RNA viruses like hand-foot-and-mouth disease have evolved ways of multiplying the functions achievable from a small genome to overcome the limitation of their small genome size. (01)