Study Unveils New Insights into Addictions of Tumors

Monday 09 October 2017 2 weeks ago 46   Islamabad   Print

File Photo.

Report  Web Desk : ISLAMABAD: Researchers report in a new study that the p62 pathway in tumor stroma could be a potential anti-cancer target. It reveals that a p62 protein deficiency helps tumors and stroma; supportive tissue surrounding the tumor to survive and grow even when being deprived of glutamine, an essential amino acid. “Cancer has traditionally been treated with chemotherapies that target oncogene addictions. The oncogenic signals that tumors use to survive,” Maria said. “We are looking at the non-oncogenic addictions, which are the function of non-mutated genes that also contribute to the survival of many cancers. For tumors to survive, they have to ensure access to adequate nutrient supplies by rewiring surrounding tissue such as cancer-associated fibroblasts in the stroma. “The cancer doesn’t have supplies. In its more aggressive forms, nutrient accessibility inside the tumor becomes limited. The tumor eliminates p62 from the stroma to make the stroma more aggressive, more inflammatory and to be able to support the disease.” Researchers found that reducing p62 increased ATF4, an essential transcription factor protein that teaches cells to adapt to situations where nutrients are of short supply in the tumor micro-environment. Losing p62 and gaining ATF4 activates a complex pathway that generates the amino acid asparagine, allowing stromal cells and tumor cells to survive and grow regardless of nutrient-poor conditions. (01)